Peter Attia· MD
everything about the way this study was done is a bit wonky some of it is justifiable but it's important to understand first the women were all way outside of menopause so none of these women were started when you would normally start HRT and um there were probably several reasons for that but one of them is and I think this is a legitimate reason they wanted hard outcomes they wanted to know death rates and if you're doing this on women in their 50s you just weren't going to get it right you couldn't wait too long yeah you got to wait too long and this was only going to be like a seven to ten year study so they had to do this on women who were much older they also disproportionately took much sicker women I believe the prevalence and again I'm going to get some of these numbers wrong and people are going to get all phosphorylated but you know I mean I'm in the ballpark right something like 30 40 of these women were smokers the prevalence of obesity diabetes was enormous so they they did they really disproportionately picked the most unhealthy population they could that was pretty advanced in age and again I think part of that was to say look we want to make sure that after seven years we really know if there's a difference in these causes of death