In individuals with Familial Hypercholesterolemia, low HDL and hypertension are stronger predictors of early heart attack than higher LDL.

“low HDL was something like a six to eight times risk towards having an early heart attack for these FH people and then they had hypertension was in the same range high blood pressure you were six to eight times more likely to be one of the guys with an early heart attack these are huge risk multipliers but they're just the normal multipliers that ordinary people have and then it went down until LDL the higher LDL people within that v fh group it was only a one point one six multiplier for risk to be much higher LDL within the group”