Abnormal presence of microbes triggers the release of zonulin, which widens gap junctions in the gut, allowing passage of large molecules and immune cells, potentially initiating inflammation.

“any abnormal presence of microbes triggers the release of the protein zonulin you guys have heard about this when the gut gets triggered it releases zulin which widens the Gap Junctions between cells so that water can move into the intestine and flush out bacteria via loose bow movements but that allows the passage of large molecules and immune cells and that is where inflammation may start”