Controversial Thoughts: Can an animal based diet help with depression/anxiety?

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Paul Saladino23m · 2021-09-17

Claims Made

50

Claims Supported

43

Support Rate

86%

Support rate

43 of 50 claims supported

43 supported7 partial / not

Claims from this content

44

Well SupportedAn animal-based diet of well-raised meat, organs, and low-toxicity plant foods is believed to be powerfully beneficial.Well SupportedFamilial partial lipodystrophy caused by LMNA mutations leads to insulin resistance and early coronary heart disease.Well SupportedIncreased dietary linoleic acid leads to increased linoleic acid and 4-HNE in adipocytes, contributing to metabolic dysfunction.Well SupportedInsulin resistance is likely at the root of many health issues, including depression, anxiety, psychosis, schizophrenia, bipolar disorder, and metabolic dysfunction.Well Supported

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Excessive dietary linoleic acid is a primary cause of insulin resistance and metabolic dysfunction.

Partially SupportedLinoleic acid breakdown products, such as 4-HNE, negatively affect fat cells and contribute to metabolic dysfunction.

Partially SupportedStudies from the 1960s and 1970s showed that psychiatric patients on gluten-free diets improved compared to those on gluten-containing diets.

Partially SupportedExorphins derived from proteins like gluten, casein, albumin, and zein can bind to endorphin receptors and cause negative effects.

Partially SupportedGut irritation from lectins and plant toxins may drive neuroinflammation and contribute to mental health disorders.

Partially SupportedDesiccated organ supplements and an animal-based diet can improve mood and energy levels.

Not SupportedElevated LDL is not the primary cause of coronary heart disease; insulin resistance and metabolic dysfunction are the main drivers.

Well SupportedDepression is accompanied by significantly higher concentrations of pro-inflammatory cytokines TNF-alpha and Interleukin-6.

Partially SupportedAnhedonia is an indicator of brain inflammation and is connected with brain insulin resistance.

Partially SupportedInsulin resistance is a shared pathogenic mechanism between depression and type 2 diabetes.

Partially SupportedMental illnesses may be primarily caused by underlying inflammation and inappropriate immune system activation in the brain.

Partially SupportedLinoleic acid accumulates in the body, impairs metabolism, and breaks down into oxidized byproducts associated with health problems.

Partially SupportedAlterations in dopamine and serotonin metabolism may be involved in the symptomatology of suicidal behavior, potentially mediated by cerebrospinal fluid IL-6.

Not SupportedSecondary drugs for mental health issues can have significant side effects and should not be used without addressing the root cause.

Partially SupportedTo treat mental illness, eliminate foods causing leaky gut and leaky brain, and remove seed oils that contribute to metabolic dysfunction and insulin resistance.

Partially SupportedInsulin resistance in the brain can alter dopamine turnover and lead to behavioral disorders.

Partially SupportedMental health is equivalent to metabolic health, with mental unwellness correlating to metabolic unwellness and inflammation.

Partially SupportedAbnormal presence of microbes triggers the release of zonulin, which widens gap junctions in the gut, allowing passage of large molecules and immune cells, potentially initiating inflammation.

Partially SupportedLeaky gut is connected to diseases such as arthritis, asthma, type 1 diabetes, and multiple sclerosis.

Partially SupportedInflammation affects neurotransmitter production and utilization in the brain, potentially causing mental health problems.

Partially SupportedDepression is the number one cause of disability worldwide, and suicide is the second leading cause of death among young people.

Partially SupportedBread consumption can increase gut permeability, prompt immune responses, and release opioid-like compounds that may cause mental derangement.

Partially SupportedGlobally, 264 million people have anxiety disorders and 50 million people have dementia.

Not SupportedGrains contain defense compounds that can cause issues in the gut and brain barriers.

Not SupportedTreating mental illnesses solely with medications that target neurotransmitters without addressing neuroinflammation and microglial cell changes is an outdated approach.

Partially SupportedA postmortem study found high rates of inflammation in the stomach (50%), small intestine (88%), and large intestine (92%) of schizophrenic patients.

Partially SupportedGluten stimulates zonulin release, increasing intestinal and blood-brain barrier permeability.

Partially SupportedAn animal-based diet is a powerful intervention for mental illness.

Partially SupportedLectins are a significant cause of gut permeability issues and can negatively impact the gut and brain barriers.

Partially SupportedGrains may not have evolved to be easily digested by humans.

Partially SupportedInsulin resistance in the brain may be caused by the same factors that cause insulin resistance in the rest of the body.

Partially SupportedCorrecting insulin resistance and metabolic dysfunction by removing grains and legumes, which cause leaky gut and blood-brain barrier issues, is foundational to health.

Partially SupportedInsulin is a critical neuropeptide for cognitive function, neuromodulation, and neuroprotection, and its absence due to brain insulin resistance impairs these processes.

Partially SupportedInsulin resistance likely develops first, followed by inflammation and autoimmunity, suggesting many chronic conditions are fundamentally metabolic dysfunction.

Partially SupportedLeaky gut and leaky brain are connected and contribute to insulin resistance and inflammation in the brain.

Partially SupportedAn animal-based diet and supplements improved body composition, increased energy, and improved mood.

Partially SupportedChanging diet, cutting out seed oils, and avoiding high-lectin foods can treat depression linked to inflammation.

Partially SupportedAn evolutionarily inconsistent diet is hypothesized to be a primary cause of autoimmune diseases and inappropriate immune system activation, including neuroinflammation.

Partially SupportedCompounds in wheat, such as gluten, can cross the gut and blood-brain barriers and interfere with nerve growth factor in rodents.

Partially SupportedGluten and other exorphins may cause the gut and blood-brain barriers to become leaky, potentially initiating inflammation and pathology.