Paul Saladino· MD
if you're overweight you've got some degree of insulin resistance
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if you're overweight you've got some degree of insulin resistance
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more than probably 90% of the American adult population have some degree they're on they're on the you know the sliding scale of insulin resistance and metabolic disease
less than twelve point two percent in fact it was 12.2% only met the guidelines so eighty seven point eight percent of the population in the US can be considered to be metabolically unhealthy this is crazy if everyone in the US looks like they have insulin resistance everyone in quotes like the majority of people in the US have insulin resistance of course apoe4 looks bad but in populations that are not insulin resistant apoe4 can even confer a benefit a Bowie for is only an issue if we are insulin resistant
we have an epidemic of insulin resistance as those papers show repeatedly that very few people have optimal metabolic health
I would argue that almost everyone if not every single person who is obese or overweight has some degree of insulin resistance and this is metabolic dysfunction.
As Americans, 86 to 93% of us, 86 93 have at least one metric that puts us on that continuum.