The Randall hypothesis suggests that competition between glucose and fat for burning can lead to diabetes because fat is a preferred fuel.

“you know i think the essence of the hypothesis is that fat is somewhere between a preferred and the preferred fuel for tissues and there's competition between carbohydrates classically glucose and fat for burning and so when fat is available then glucose tends not to be burned effectively and that's a possible cause of diabetes”

“this is a very old idea called the randall hypothesis but but i think there's a lot of truth to it we have a lot of new data that's consistent with it and so i think a lot of these issues come back to making room for glucose to be burned by controlling the amount of fat that's being used by tissues so can you state for folks the randall hypothesis”

“the Randall hypothesis was that fatty acids the diog glycerol cause all the problems and what Bob wolf did was basically run that experiment with st stable isotopes and he showed it's actually the reverse that fatty acids are not inherently toxic but glucose is it has its own disease we call it diabetes”