ApoC3 is increased in states of insulin resistance and may cause LDL particles to be retained in the subendothelial space.

“well what is hyperinsulinemia doing in this equation it is pressing harder on the throttle it is accelerating through mechanisms uh like you know upregulation of apoc3 expression which regulates apob in the wrong direction right so more APO C3 means more APO B it impacts the LDL receptor the LDL receptor related protein it moves all of these things in the wrong direction so insulin is um um basically changing the amount of uh LDL particle that you have in in circulation”

“person has for example type 2 diabetes which we'll talk about in a second that is generally accompanied by hyperinsulinemia well what what is hyperinsulinemia doing in this equation it is pressing harder on the throttle it is accelerating through mechanisms uh like you know upregulation of apoc3 expression which regulates apob in the wrong direction right so more APO C3 means more APO B it impacts the LDL receptor the LDL receptor-related protein it moves all of these things in the wrong direction so insulin is um um basically changing the amount of uh LDL particle that you have in in circulation”