Aging women's eggs held longer in metaphase combined with declining metabolic health can lead to chromosome abnormalities.

“When you are 40, 40 years have passed. We've asked those chromosomes to hold there longer. I always say if I have a line of kindergarteners and I ask them to stand for 40 years, like somebody's going to get out of line. So tincture of time adds up. But the other thing that happens as we get older is as a population we get more metabolically unhealthy. So we see more chronic inflammation, more insulin resistance, more obesity. And all of those factors influence oxidative stress, mitochondrial health, DNA damage. They can damage the myotic spindles holding those chromosomes apart. So we also see more genetic abnormalities as we age but that is worsening as metabolic health worsens too.”