Processed sugar intake can lead to gut dysbiosis, increasing endotoxin (lipopolysaccharide) levels, which triggers inflammation and mitochondrial dysfunction.

“sugar is bad for humans but not because of why we think it is sugar is bad for humans because it causes dispos and endotoxemia that's the problem insulin induced insulin resistance that's not the problem with sugar”

“So in myself and many other people I've seen this but I'm pretty sure that if I ate sugar an equivalent amount of spoonful and this is the counter rejuctionist perspective that over time I would change my gut flora or I would increase the lipopolyaccharide that I might become less insulin sensitive and that I think that probably would happen for me.”

“When I give a human sucrose, pure glucose, pure fructose, we really do see changes in the gut microbiome that result in increased endotoxin, increased LPS, lipopolyaccharide, which is a component of the gram negative cell wall. And there are other endotoxins, but this is the main one is lipopolyaccharide. And there's pretty good evidence that when you have endotoxmia, when you have increased levels of endotoxin in your blood, your body mounts an inflammatory response and your mitochondria kind of shut down.”

“and that causes you to become insulin resistant due to an inflammatory mechanism.”

“So when you just feed humans pure sugar you get overgrowth of the wrong bacteria in the gut and those wrong bacteria produce lipopolysaccharide from the cell membranes. This is gram negative endotoxin right and that endotoxmia leads to mitochondrial dysfunction. This is one mechanism by which humans become insulin resistant.”