High plasma non-esterified fatty acids (NEFA) are causally related to abnormalities in carbohydrate metabolism.

“the original paper by pj randall which i'll show here on the screen the title is the glucose fatty acid cycle its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus and if you read this he says we now wish to summarize evidence which appears to show that the high plasma concentrations of nepha which is the which are non-esterified fatty acids in parentheses or the underlying breakdown of glycerides of which it is a symptom uh stands in a causal relationship to these abnormalities of carbohydrate metabolism”