Don’t fear the Randle cycle

PS

Paul Saladino8m · 2022-08-05

Claims Made

20

Claims Supported

3

Support Rate

15%

Support rate

3 of 20 claims supported

3 supported17 partial / not

Claims from this content

16

Partially SupportedWhen following a ketogenic diet, the body becomes physiologically insulin resistant, sparing glucose for essential functions while muscles utilize ketones.Partially SupportedThe glucose-fatty acid cycle suggests that products of fatty acid metabolism favor the continuation of fatty acid metabolism and is fundamental to controlling blood glucose and fatty acid concentrations and insulin sensitivity.Partially SupportedThe body preferentially uses the fuel source that is already in use, meaning it will not be in ketosis if metabolizing glucose.Partially SupportedThe Randle cycle describes substrate-level competition where the body preferentially uses the fuel source currently being metabolized.

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Partially Supported

When metabolizing glucose, breakdown products of the Krebs cycle inhibit carnitine palmitoyltransferase, which is involved in shuttling fatty acids for beta-oxidation.

Not SupportedPhysiologic insulin resistance in ketosis results from fat cells releasing free fatty acids when insulin is low, signaling the body to become insulin resistant.

Partially SupportedEating an animal-based diet, which includes fruit and animal fats together, leads many people to lose weight and become leaner.

Partially SupportedConsuming carbohydrates from fruit with fat is biochemically normal and acceptable.

Partially SupportedPaul Saladino's non-esterified fatty acid levels are 0.12 on a diet including carbohydrates, compared to 0.6 on a ketogenic diet.

Partially SupportedHuman biochemistry normally favors glucose metabolism, which is not problematic and does not lead to weight gain.

Partially SupportedHigh plasma non-esterified fatty acids (NEFA) are causally related to abnormalities in carbohydrate metabolism.

Partially SupportedThe Randle cycle does not imply that consuming fat with carbohydrates causes fat storage; the body prioritizes glucose during a meal but can burn fat later if metabolically healthy.

Partially SupportedGlucose in the environment signals the body to prioritize using glucose over burning fatty acids.

Partially SupportedThe products of beta-oxidation inhibit pyruvate dehydrogenase, contributing to abnormalities in carbohydrate metabolism.

Not SupportedAttempting to remain in ketosis all the time can lead to electrolyte problems and testosterone issues.

Not SupportedThe idea that eating carbohydrates and fat together will cause weight gain is a misunderstanding of the Randle cycle.