The glucose-fatty acid cycle suggests that products of fatty acid metabolism favor the continuation of fatty acid metabolism and is fundamental to controlling blood glucose and fatty acid concentrations and insulin sensitivity.

“The original paper by pj randall which i'll show here on the screen the title is the glucose fatty acid cycle its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus and if you read this he says we now wish to summarize evidence which appears to show that the high plasma concentrations of nifa which is the which are non-esterified fatty acids in parentheses or the underlying breakdown of glycerides of which it is a symptom stands in a causal relationship to these abnormalities of carbohydrate metabolism”

“the randall cycle is talking about the reasons we become physiologically insulin resistant when you avoid carbohydrates and the fact that when you add back carbohydrates that process will then damp down fatty acid metabolism”

“we wish to propose further that there are interactions between glucose and fatty acid metabolism in muscle and adipose tissue which take the form of a cycle the glucose fatty acid cycle and which are fundamental to the control of glucose and fatty acid concentrations in the blood and of insulin sensitivity”