Paul Saladino· MD
insulin resistance as being a sort of like rosetta stone of modern chronic disease I really think it is
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
insulin resistance as being a sort of like rosetta stone of modern chronic disease I really think it is
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
that's why i think like that's where the sort of ancestral evolutionary paradigm is so fascinating to me like what if it what if humans can be really pretty freaking good if we take care of our circadian rhythm get some real sunlight eat foods that are evolutionarily consistent we can debate what those are or not and you know and then try and avoid toxins and then do things that you care about and try not to get super stressed and you know like have a meaningful life and a community that supports you like that's pretty simple and i love the simplicity of that ancestral message it's like hey like don't don't you don't need to take nr nmn just be insulin sensitive and that to me is why that that's such a focus of what i do because i see that over and over and over in the work that insulin resistance aka metabolic dysfunction is at the center of so many chronic illnesses that it's understanding how to correct that is so critical
Metabolic dysfunction also known as insulin resistance is that continuum and that pathology underlies I would say 90 plus% of chronic illness and this is not hyperbole.