When individuals have metabolic dysfunction, their thyroid cells may not respond properly to insulin signals, potentially affecting T4 to T3 conversion.

“what we find this article should be titled metabolic dysfunction is associated with an increased you know reverse t3 or a lower t3 to reverse t3 ratio”

“when someone has metabolic dysfunction the cells of their thyroid are not going to respond to insulin either and the cells of the periphery where just places in the periphery where those deionizers may be working right insulin certainly has a role here i imagine that insulin has a signaling role in converting t4 to reverse t3 versus t3 and if those things are not properly signaled if cells are not seeing that signal properly that is going to get thrown off”