Paul Saladino· MD
the mechanism by which our body orchestrates insulin resistance with over feeding is inflammation the body signals from the mitochondria these reactive oxygen species to the cell to say become insulin resistant
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the mechanism by which our body orchestrates insulin resistance with over feeding is inflammation the body signals from the mitochondria these reactive oxygen species to the cell to say become insulin resistant
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at the level of the mitochondria this is where insulin resistance starts insulin resistance is a normal process that can go wrong when there is too much linoleic acid in our body linoleic acid polyunsaturated fats signal to our mitochondria that reactive oxygen species are are a signal that reactive oxygen species should not be produced the cells remain insulin sensitive this can be it can be misconstrued in the short term but at the level of the adipocyte it means those grow and eventually they get pathologically large which causes major problems
the mitochondria and the adipocytes can signal with reactive oxygen species yes to the insulin receptor at the surface of the adipocyte and say hey become insulin resistant so the adipocytes don't grow
So, why do you become insulin resistant at the level of the muscle and the level of the liver? I believe it's because of inappropriate signaling connected with too much linoleic acid, as I mentioned earlier, seed oils leading to inappropriate signaling originating in the mitochondria.
So from a whole energy perspective, linoleic acid looks to be very bad. And when we're not producing energy efficiently, we become insulin resistant. It's sort of this cell danger response or at least a a reactive response in the cell saying, "Hey, we're not making energy."