The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
there's some very uh pivotal work out of Yale and they looked at young healthy college students you know as a college student you'll do anything for a couple bucks right and they pay them um and these individuals were sedentary and what they but they were healthy lean and what they saw was skeletal muscle insulin resistance just by being inactive
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their free fatty acids were high the non-esterified free fatty acids in the blood were high and that that was driving the insulin resistance quote unquote at the level of the muscle
What we wanted to do was actually ask the question what we see in these young 20 year olds these volunteers is the first thing we see is muscle insulin resistance and maybe that's driving atherogenic dyslipidemia it's going to lead to heart disease high triglycerides low hdl and non-alcoholic fatty liver disease by changing the fate of ingested carbohydrate from glycogen to fat
to test our overall hypothesis does muscle insulin resistance drive fatty liver and dnl and high triglycerides