Mice fed excess seed oils develop hyperinsulinemia and hyperleptinemia but not hyperglycemia, indicating hyperglycemia requires beta cell destruction to cause severe heart failure.

“for instance increasing their seed oil intake gives them the mouse equivalent of diabetes where they get hyperinsulinemia and hyperleptinemia right which is both high levels of insulin and high levels of leptin but they don't get hyperglycemia mice don't get hyperglycemia in their equivalent of type 2 diabetes so what they have to do is kill their beta cells and that induces hyperglycemia when you induce failure of half of their beta cells they get severe heart failure in four days”