Insufficient sleep impairs glucose homeostasis by negatively affecting both insulin release from pancreatic beta cells and insulin sensitivity in body cells.

“firstly we know that when you are under slept the beta cells of your pancreas become insensitive to the spike in blood sugar glucose in other words your body stops releasing enough insulin to deal with the food that you've just eaten so you're down on insulin you haven't released enough insulin that's a bad thing”

“what's worse that the cells of the body actually become insensitive to the signal of insulin and so the cells of the body stops sucking in as much glucose as much sugar from the bloodstream”

“when you are not getting sufficient sleep, the beta cells in your pancreas stop being sensitive to the signal of high glucose. So the beta cells...they release insulin. And that insulin will drop your blood glucose. But those cells had become insensitive to glucose, what we call sort of glucose insensitivity. And so the beta cells of the pancreas stopped releasing as much insulin.”

“he discusses how sleep restriction causes the beta cells in the pancreas to stop becoming sensitive to glucose and this in turn affects how much insulin is produced”

“when you are not getting sufficient sleep the beta cells in your pancreas stop being sensitive to the r to the signal of high glucose so the beta cells which normally are listening for this Spike and glucose and as soon as they sort of you know hear they're not hearing it they're sensing it but as soon as they sense the spike and glucose they release insulin and that insulin will drop your BL blood glucose but those cells had become insensitive to glucose what we call GL sort of glucose insensitivity um and so the beta cells of the pancreas stopped releasing as much insulin it didn't release enough insulin to drop blood glucose so blood glucose remained high”

“To me, it made it very real. I was like, "This really is regulating my insulin level, my insulin sensitivity."”