Paul Saladino· MD
Multiple studies show that "naked" sugar can lead to dybiosis in the gut and raise LPS (endotoxin), leading to inflammation and IR (PMIDs: 32397233,34201938).
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
Multiple studies show that "naked" sugar can lead to dybiosis in the gut and raise LPS (endotoxin), leading to inflammation and IR (PMIDs: 32397233,34201938).
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Processed sugar stripped naked sucrose causes dispiosis at the level of your gut. Overgrowth especially if gram negative bacteria leads to increase in something called lipopolyaccharide or endotoxin that seeps into your bloodstream and the resulting inflammation from increased levels of LPS can worsen can add fuel to the fire of metabolic dysfunction and insulin resistance.