Paul Saladino· MD
humans physiologically become insulin resistant when they have an infection correct for probably for many of these reasons
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
humans physiologically become insulin resistant when they have an infection correct for probably for many of these reasons
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and so it seems that what's happening with a lot of chronic disease now is that we're becoming insulin resistant inappropriately we're getting inflammation inappropriately but inflammation and insulin resistance go hand in hand from an evolutionary perspective because our body wants all of this to happen and perhaps we could even then take a step further and say evolutionarily when we get inflammation when we're trying to fight a pathogen it makes sense that inflammation would trigger insulin resistance for all these reasons correct
there is this interesting evolutionary advantage to being insulin resistant during certain times and one of those is infection
and so it is also clear that inflammation in the body whether it's responding to an infection or an oxidative stress can trigger insulin resistance as I talked about with Dave and Siobhan that's probably an evolutionary mechanism by which we shown tree sources yeah and we trigger the immune system to be more active and I think it's getting activated you know inappropriately today because we're exposed to more oxidative stress it's not an inflammatory issue per se in the sense that it's not an infectious issue yeah but the body has a system in place whereby it responds to infectious issues with inflammation and insulin resistance yeah okay that is awesome I think hopefully that'll be a good discussion I don't think we can ever talk about insulin resistance too much so and but one thing that that really bothers me and in the insulin resistance space is that so like Tim Noakes has recently gone a lot of like good publicity because he's been he's been writing blogs for the CrossFit website talking about like why a cardiovascular diseases the insulin resistance and like yes that's true but what is it that causes in services like you don't just get you know aegis it's not contagious you don't just get it spontaneously so yes insulin resistance may be the causative or like the the thing that that binds all these problems together but what is it that causes insulin resistance and it's that this eeveelution mismatch the the lack of these factors that you know in terms of good nutrition sleep movement maybe even social connection which act you know if you're socially isolated that inadvertently or inappropriately activates the immune system so all of this stuff is why against the resistance so when people talk about while I'm instant resistant therefore I reduce my carbohydrate intake yes you can't do that but it doesn't really make any sense to me because I'm fixed what caused the insulin resistance in the first place it wasn't just eating too many carbohydrates like because there are plenty of there are plenty of populations around the world who do all the things that