The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
and the liver as you said is incorrectly gluconeogenesis at ease the liver has its headband on it's got a big fro and it is gluconeogenesis izing like crazy and making glucose from all this substrate and that's what I love that you pointed that out that high levels of glucose in pathologic insulin resistance are predominantly related to just the liver gluconeogenesis I'm like crazy like because of the signaling that's different so these are very different states Yeah right
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the liver as you said is incorrectly gluconeogenosizing like jazzercise the liver has its headband on it's got a big fro and it is gluconeogenosizing like crazy and making glucose from all this substrate and that's what i love that you pointed that out that high levels of glucose in pathologic insulin resistance are predominantly related to just the liver gluconeogenesizing like crazy like because of the signaling that's different
Pathological insulin resistance and that is the case that you're describing where the adipocytes are releasing fat and there's all these substrates coming to the liver and gluconeogenesis does appear to be at least somewhat supply driven and the liver as you said is incorrectly gluconeogenosizing like jazzercise the liver has its headband on it's got a big fro and it is gluconeogenosizing like crazy and making glucose from all this substrate and that's what i love that you pointed that out that high levels of glucose in pathologic insulin resistance are predominantly related to just the liver gluconeogenesizing like crazy like because of the signaling that's different so these are very different states
in the latter insulin is actually high and there can be carbohydrates present and because insulin is high and the liver is insulin resistant you have inappropriate gluconeogenesis in pathological insulin resistance and that leads to elevated blood sugars