The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
If your fat cells are broken and they can't expand, increasing the number of fat cells will improve your insulin resistance, but then you get fatter, which isn't a good thing long-term, either. Look at this paper from 2007. Obesity-associated improvements in the metabolic profile through expansion of the adipose tissue.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
So, TZDs make you fatter. And making you fatter improves insulin resistance, it turns out. I'm not saying we should have more fat people, so there's less insulin-resistant people, but expansion of fat mass improves insulin resistance, at least in the short term.