How to reverse high blood pressure

PS

Paul Saladino1h 5m · 2022-09-20

Claims Made

162

Claims Supported

131

Support Rate

81%

Support rate

131 of 162 claims supported

131 supported31 partial / not

Claims from this content

121

Well SupportedExcessive lipolysis and broken fat cells, potentially caused by polyunsaturated fatty acid breakdown products like linoleic acid, can lead to insulin resistance.Well SupportedA fasting insulin level below 5 micro IU/mL is considered healthy.Well SupportedThe Hadza people feed their children meat and fruit and generally do not eat vegetables, leaves, stems, or seeds unless necessary.Well SupportedIndigenous populations studied typically consume diets where linoleic acid constitutes about 2% of fat intake, contrasting with 7-15% in Western diets.Well Supported

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Broken fat cells cause insulin resistance, and fixing them may lead to weight gain if dietary habits remain unchanged.

Well SupportedAtherosclerosis does not develop in veins, suggesting that endothelial damage is necessary for its initiation.

Well SupportedSystolic blood pressure does not significantly increase with age in the Hadza population.

Well SupportedFamilial partial lipodystrophy caused by LMNA mutations leads to insulin resistance and early coronary heart disease.

Well SupportedImpaired wound healing at the endothelial level in individuals with insulin resistance prevents proper repair, leading to the initiation of atherosclerosis.

Well SupportedPaul Saladino remains insulin sensitive despite significant carbohydrate consumption due to his blood work foundation and not being obese or diabetic.

Well SupportedReducing linoleic acid intake is predicted to be the most significant health improvement.

Well SupportedHypertension is primarily caused by insulin resistance unless a secondary cause is identified.

Well SupportedHypertension is not treated as an insulin-resistant process despite insulin resistance and hypertension being known as correctable since 1990.

Well SupportedDiabetics and insulin-resistant individuals have impaired immunity and wound healing.

Well SupportedFree-living human populations exist that are free from chronic diseases such as obesity, diabetes, cardiovascular disease, autoimmunity, cancer, depression, and dementia.

Well SupportedExcess insulin leads to increased sodium resorption and is associated with high blood pressure in individuals with high fasting insulin.

Well SupportedOnly 12.2% of the population surveyed in NHANES (2009-2016) were metabolically healthy.

Well SupportedWhen fat cells become hypertrophic, they release inflammatory mediators and experience macrophage infiltration, which is associated with insulin resistance and vascular endothelial dysfunction.

Not SupportedExcessive sodium restriction can cause misery, orthostatic hypotension, potential erectile dysfunction, and activate the renin-aldosterone system.

Well SupportedDesiccated organ supplements from grass-fed sources can support organs and benefit individuals with GI issues.

Well SupportedMetabolic syndrome is characterized by five biomarkers: abdominal obesity, high blood pressure, high glucose levels, high triglycerides, and low HDL cholesterol.

Well SupportedA blood pressure reading of 120/80 mmHg is considered normal.

Well SupportedLess than 1% of medical students in the United States understand the phenomenon of nutrition's impact on health.

Well SupportedAdrenocortical hyperfunction, Cushing's syndrome, and primary aldosteronism are endocrine causes of secondary hypertension.

Well SupportedIn healthy, insulin-sensitive individuals, sodium intake does not cause chronic hypertension, although it may temporarily increase blood volume and pressure.

Not SupportedHigh blood pressure and high cholesterol are not caused by aging but by living in an evolutionarily inconsistent way, and these conditions are correctable and reversible.

Partially SupportedInsulin resistance and resultant hyperinsulinemia are linked to hypertension and can be corrected with dietary changes.

Partially SupportedExcessive sodium conservation by aldosterone can lead to hypertension, independent of dietary sodium intake.

Partially SupportedIndividuals on an animal-based diet can consume sufficient potassium from fruit and meat without needing vegetables.

Partially SupportedInsulin resistance, driven by exceeding personal fat threshold, can lead to premature atherosclerosis even without elevated LDL.

Partially SupportedExcessive consumption of linoleic acid causes fat cells to break down by altering cell membrane signaling.

Well SupportedDiabetics experience abysmal wound healing, with even minor injuries potentially leading to amputation.

Partially SupportedInsufficient insulin signaling at the kidney can lead to electrolyte imbalances in individuals on ketogenic diets.

Partially SupportedAdopting ancestral dietary patterns can help humans return to a state of health.

Partially SupportedIncreasing the number of fat cells can improve insulin resistance but leads to increased body fat and potential long-term health issues.

Partially SupportedDiet and lifestyle interventions should be the first line of treatment for health issues.

Well SupportedFor individuals with hypertension for whom only lifestyle modifications were recommended, essentially all remained uncontrolled.

Partially SupportedAn animal-based diet including meat, organs, supplements, hamburger, and fruit is a preferred dietary pattern.

Partially SupportedTZD medications like pioglitazone can improve insulin resistance by promoting fat cell division, but may cause weight gain.

Partially SupportedExposure of adipocytes to physiological low concentrations of 4-HNE promotes oxidative stress, impairs adipogenesis, alters adipokine expression, increases lipolytic gene expression, and increases free fatty acid release.

Partially SupportedAn animal-based diet, combined with desiccated organ supplements, improved energy, mood, resilience, and resolved chronic severe cholinergic urticaria, dryness, redness, and inflammation.

Not SupportedExcess salt in the diet can worsen hypertension but is not considered a root cause.

Not SupportedExcess potassium intake does not correct hypertension; the root cause must be addressed.

Not SupportedWestern medicine often tells patients with primary hypertension that there is no cure, the cause is unknown, and medication is the only option, with dietary advice being rare and often incorrect.

Not SupportedWestern medicine often treats menstrual irregularities with interventions that do not address root causes like insulin resistance.

Not SupportedHypertension is primarily caused by insulin resistance, not salt, and can be improved by addressing insulin resistance.

Partially SupportedRemoving an aldosterone-secreting adrenal tumor successfully treated severe hypertension unresponsive to multiple medications.

Partially SupportedPrimary hypertension is a chronic, reversible illness managed with diet and lifestyle modifications.

Partially SupportedRisk factors for hypertension include high sodium intake, low potassium intake, obesity, alcohol consumption, physical inactivity, and unhealthy diet.

Partially SupportedPrimary hypertension is considered age-related in Western medicine, with systolic blood pressure increasing per decade of aging.

Partially SupportedArteries are susceptible to atherosclerosis due to being a higher-pressure system that damages vessel walls.

Partially SupportedHypertension combined with insulin resistance leads to accelerated atherosclerosis due to delayed wound healing of arterial damage.

Partially SupportedRenal artery stenosis can cause hypertension.

Partially SupportedElevated fasting insulin concentrations are independently associated with an increased risk of hypertension.

Partially SupportedAldosterone-producing tumors can cause hypertension by activating the renin-angiotensin-aldosterone axis.

Partially SupportedIndividuals with hypertension or insulin resistance should prioritize reducing linoleic acid intake.

Partially SupportedHypertension is the leading cause of cardiovascular disease and premature death worldwide.

Partially SupportedStress can cause temporary hypertension, but blood pressure should return to normal.

Partially SupportedPrimary hypertension accounts for approximately 97-98% of cases.

Partially SupportedSystolic and diastolic blood pressure do not increase with age in free-living wild human populations.

Partially SupportedAcromegaly can cause hypertension.

Partially SupportedInflammation in the renal arteries can cause hypertension.

Partially SupportedCongenital adrenal hyperplasia can cause secondary hypertension.

Partially SupportedHypertension and atherosclerosis often share common root causes.

Partially SupportedSevere hypo- or hyperthyroidism can cause hypertension.

Partially SupportedPheochromocytoma, a rare tumor, can cause hypertension.

Partially SupportedACE inhibitors block the angiotensin-converting enzyme, preventing angiotensin I from becoming angiotensin II, but this leads to decreased breakdown of bradykinin and a dry cough.

Partially SupportedDirect renin inhibitors, like Tekturna, block renin's action in converting angiotensinogen to angiotensin I.

Partially SupportedAligning diet with evolutionary consistency, increasing exercise, sunlight exposure, and avoiding environmental toxins are crucial for health.

Not SupportedAngiotensin receptor blockers, ACE inhibitors, and direct renin inhibitors used to treat hypertension can cause electrolyte issues and angioedema; ACE inhibitors specifically cause a dry cough due to bradykinin.

Not SupportedCalcium channel blockers can cause peripheral edema, orthostasis, falls, and orthopedic injuries.

Partially SupportedActivating PPAR gamma can increase fat mass and potentially fix issues related to fat cells, but does not address the root cause of insulin resistance long-term.

Partially SupportedImproving insulin resistance with medications like pioglitazone can temporarily improve hypertension and depression, but does not fix the underlying cause and leads to weight gain.

Partially SupportedThe Hadza traditionally have no seed oils in their diet.

Partially SupportedRecommended lifestyle practices include moderate exercise, strength training, sun exposure, and avoiding toxins.

Not SupportedDietary recommendations for hypertension, such as lowering salt intake, do not correct the root cause and can create additional problems.

Partially SupportedLowering dietary linoleic acid intake reduces the synthesis and accumulation of oxidized linoleic acid metabolites implicated in pathological conditions.

Not SupportedLoop diuretics and thiazide diuretics can cause deficiencies in B vitamins, magnesium, and other minerals.

Partially SupportedFamily history of hypertension, cardiovascular disease, dementia, stroke, or cancers are predispositions that manifest based on lifestyle choices, not predetermined outcomes.

Partially SupportedSecondary causes of hypertension are much rarer than primary hypertension.

Partially SupportedObstructive sleep apnea is a potential cause of secondary hypertension.

Partially SupportedPregnancy can alter blood pressure and potentially cause hypertension.

Partially SupportedDespite widespread use of antihypertensive medications, global mean blood pressure has remained constant or decreased slightly over the past four decades, but the prevalence of hypertension has increased.

Partially SupportedExcess insulin in a state of hyperinsulinemia leads to increased sympathetic tone, increased angiotensin 2 production, decreased nitric oxide formation, and potentially adverse lipid profiles.

Partially SupportedChronic conditions like kidney disease, diabetes, and sleep apnea are considered correctable causes of hypertension, often classified as secondary hypertension.

Partially SupportedPioglitazone improves blood pressure and metabolic markers in patients with type 2 diabetes.

Partially SupportedA prolactin-secreting adenoma in the pituitary gland may be associated with multiple endocrine neoplasia and contribute to hormonal imbalances.

Partially SupportedA small percentage of people with hypertension in the US achieve blood pressure control below 140/90 mmHg, and fewer below 120/80 mmHg.

Partially SupportedDrinking too much alcohol can cause hypertension.

Partially SupportedActivating PPAR gamma can improve fat cell function and reduce inflammation but leads to significant obesity.

Partially SupportedIn the Nurses' Health Study, 39% of nurses were obese or overweight.

Partially SupportedAngiotensin II receptor blockers mitigate downstream effects of angiotensin II, such as sympathetic activity.

Partially SupportedHyperinsulinemia can contribute to bone mineral loss and osteoporosis in women.

Partially SupportedExcessive sodium restriction can activate the renin-angiotensin-aldosterone system, leading to increased aldosterone and renin levels as the body attempts to conserve sodium.

Partially SupportedPioglitazone may induce remission of major depressive episodes and act as an antidepressant.

Partially SupportedAn ideal daily sodium intake is approximately 3-4 grams, with individual needs varying.

Not SupportedIndividuals treated with PPAR gamma agonist drugs likely have undiagnosed metabolic comorbidities.

Partially SupportedIn 99% of primary hypertension diagnoses, patients are told there is no cure, the cause is unknown, and medication is the only option, with only a small percentage receiving dietary advice.

Partially SupportedThere exists a medication that can correct the root cause of hypertension, though it may have negative side effects for humans.

Partially SupportedDietary and lifestyle changes for hypertension are rarely counseled by doctors, with advice often limited to salt restriction.

Partially SupportedIdentified risk factors for hypertension include high sodium intake, low potassium intake, obesity, alcohol consumption, physical inactivity, and unhealthy diet.

Partially SupportedThe insulin-sensitizing drug pioglitazone reduces cardiovascular events in high-risk patients with type 2 diabetes.

Partially SupportedInsulin resistance and the associated syndrome contribute to unexplained cardiovascular risk in patients with type 2 diabetes.

Partially SupportedInsulin resistance is a root cause of hypertension, atherosclerosis, and depression.

Partially SupportedReducing linoleic acid intake to 2% of calories by eliminating seed oils, avocado oil, and olive oil, and focusing on animal fats like tallow and butter, can improve obesity, insulin resistance, and hypertension.

Partially SupportedObesity and metabolic syndrome disrupt immune system function, impacting pathogen defense and tissue repair.

Partially SupportedIncreased dietary linoleic acid intake leads to higher levels of linoleic acid breakdown products like 4-HNE and HODEs.

Partially SupportedDiabetes mellitus impairs wound healing due to factors like limited neutrophil functioning, malnutrition, and increased catabolic hormones.

Partially SupportedTZD class medications improve insulin resistance but may not be used for blood pressure management due to weight gain side effects.

Partially SupportedIndividuals with familial partial lipodystrophy have lower LDL but significantly higher fasting insulin and a greater prevalence of hypertension.

Partially SupportedMassive visceral adiposity leads to inflammation, leakage of fatty acids, and insulin resistance.

Partially SupportedImproving insulin resistance with pioglitazone can improve atherosclerosis and cardiovascular outcomes.

Partially SupportedBeing insulin sensitive is essential to repair blood vessels and prevent cardiovascular disease.

Not SupportedHypertension is not an inevitable consequence of aging, according to data from hunter-gatherer tribes.

Not SupportedBeta-blockers used for hypertension can cause side effects including slowed pulse, erectile dysfunction, and depression.

Partially SupportedDunnigan type familial partial lipodystrophy prevents expansion of subcutaneous adipose tissue, causing fat accumulation in facial, truncal, and visceral regions.

Partially SupportedLow triglycerides, high HDL, low fasting insulin, and not being obese indicates metabolic elite status.

Partially SupportedConsuming high amounts of sodium does not cause chronic hypertension in an insulin-sensitive individual.

Partially SupportedThe renin-angiotensin-aldosterone system is a survival mechanism for blood loss and dehydration but is detrimental when over-activated in hypertension.

Partially SupportedIn the US, 116 million people (47.3% of the population) had hypertension according to 2017 data from NHANES 2015-2018.

Not SupportedStatins are not ideal for human health due to concerns about root causes of hypertension.