The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
metabolic syndrome has five biomarkers you know abdominal obesity blood pressure um uh glucose high levels of glucose and then high triglycerides and low HDL cholesterol those are the five biomarkers of metabolic syndrome
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Now, features of the metabolic syndrome, as they detail here, are increased waist circumference, increased fasting glucose, increased hemoglobin A1c, increased blood pressure, systolic over 120 or a diastolic over 180, a diastolic over 80, triglycerides greater than 150, and HDL less than 40 or 50 for men and women, respectively, not taking any medication.
they have normal blood pressure they do not have elevated blood pressure and again and they're not on medication and they're not taking medication to lower blood pressure and normal is now being much more stringently defined but i believe the latest cdc definition of normal is less than 130 over 80. in our practice we advocate less than 120 over 80. they have normal fasting glucose and that's defined as less than 100 they have normal triglycerides which are being defined as less than 150 we argue in our practice that's very high and anything over 100 is elevated totally agree they have normal hdl cholesterol which for men is defined as greater than 40 milligrams per deciliter for women greater than 50 milligrams per deciliter and they do not have truncal obesity and i forget i think for men that's defined as 40 inches of waist circumference in women 36
the quickest and easiest and dirtiest way to define metabolic health is probably to use the criteria for metabolic syndrome so metabolic syndrome is basically defined in a somewhat binary fashion which is you have three or more of the five criteria or you don't those five criteria are trunkal obesity high blood pressure high fasting glucose High fasting triglycerides and low HDL cholesterol
so one way that we typically can see if a person is kind of a metabolic mess is looking at their lipids so sometimes a person will have very high ldl very high triglycerides and very low hdl and in fact the condition of metabolic syndrome is partially defined by two of those so again for everybody's remembrance what is metabolic syndrome so it's a syndrome that is meant to closely approximate insulin resistance and it's defined by having three at least three of the following five things waste above a certain circumference that differs from men and women but basically truncal obesity high blood pressure low hdl cholesterol high triglycerides and high fasting blood sugar