Paul Saladino· MD
The authors say that obese individuals are at a greater risk for chronic disease, often present with clinical parameters of metabolic syndrome, insulin resistance, and systemic markers of chronic low-grade inflammation. It has been well established that the cells of the immune system play an important role in the pathogenesis of obesity and metabolic syndrome-related diseases, evidenced by leukocyte activation and dysfunction in metabolic tissues such as adipose tissue, liver, pancreas, and the vasculature. Recent findings have highlighted the substantial impact that obesity and metabolic syndrome parameters have on immunity and pathogen defense, including the disruption of lymphoid tissue integrity, alterations in leukocyte development phenotypes activity and the coordination of the innate and adaptive immune system, those two immune system branches.