Andrew Huberman· PhD
small adipocytes are more insulin sensitive
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
small adipocytes are more insulin sensitive
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when the fat cells are insulin resistant the body becomes insulin sensitive and vice versa
you want your fat cells to be insulin resistant because when insulin binds to the surface of an adipocyte that is going to trigger if that fat cell is insulin sensitive you that fat cell will take up uh glucose and will take up lipids via lipoprotein lipase and that fat cell will grow you want your fat cells to be insulin insulin resistant
the fat cells and the the abdominal adipose cells and the rest of the body are inverse if you have insulin resistant adipose cells you will have an insulin sensitive body if you have insulin sensitive adipocytes in your belly you will have an insulin resistant body
you want your fat cells to be insulin resistant because when insulin binds to the surface of an adipocyte that is going to trigger if that fat cell is insulin sensitive you that fat cell will take up glucose and we'll take up lipids via lipoprotein lipase and that fat cell will grow you want your fat cells to be insulin send insulin resistant
so you want your visceral adipose tissue which is actually an endocrine organ that we never really talk about you want that part of your body to be insulin resistant because you don't want your visceral visceral adipose tissue to grow
you actually want your fat cells according to this model you want we want our fat cells to be insulin resistant because that means they don't grow
you want your adipocyte to be insulin resistant because you want that adipocyte to not grow you want that adipocyte to send out the fats that are in it to the rest of the body so that you can burn your stored fat
insulin resistance essentially The Ground Zero for that is in the adipocytes in the fat cells and that broken fat cells send out inflammatory potentially aberant signals to the rest of the body creating pathological insulin resistance in the body so that there are these adipocytes that have had their ability to become hyperplastic and they're stuck in kind of this hypertrophic phase they're dysfunctional adipocytes in insulin resistance
so they have liver insulin resistance but they're adipocytes are insulin sensitive because they keep storing