Artificial sweeteners can cause counterintuitive disturbances in glycemic responses in mice, driven by their microbiome.

“The artificial sweeteners is a good example, and although, the mechanism wasn't well delineated and how this is impacting the microbiota. It certainly appeared that artificial sweeteners and they looked at three different classes of artificial sweeteners. All affect the microbiota and go on and impact insulin resistance in the host.”

“when you exposed mice to saccharin at different doses and took the microbiome after this exposure and transferred it into germ-free mice that never saw saccharine, they developed the same disturbances in blood sugar control as those of the donor mice.”