Paul Saladino· MD
one of the interesting things that I learned recently about a post III as an aside is that a possi 3 is increased in states of insulin resistance
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
one of the interesting things that I learned recently about a post III as an aside is that a possi 3 is increased in states of insulin resistance
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and we know that insulin resistance can increase the amount of a PO c3 on the LDL particle that also makes the LDL stickier
A plus c3 is you know peter is over expressing insulin resistance situations
a plus c3 is you know peter is over expressing insulin resistance situations
the impact that insulin and insulin resistance has on the expression of apoc3 so APO C3 is an is another lipoprotein so April lipoprotein C3 it's a very interesting one it's probably come up on a previous podcast perhaps where I it might have been on the one with near barceli I know I write about it in the book but it is one of the uh genes so the APO C3 Gene is one of the sort of centenarian genes so centenarians are more likely to have a version of that Gene that results in lower expression