Paul Saladino· MD
and you might see higher shbg in in older populations you know those who live longer often have higher shbg
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
and you might see higher shbg in in older populations you know those who live longer often have higher shbg
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unless it's low because then this is probably somebody who has insulin resistance or metabolic disease
And then, what we also know is that people who have high levels of insulin have lower levels of serum-hormone binding globulin, something called SHBG which binds estrogen. So it can prevent it from being active.