Muscle contraction stimulates pathways that translocate GLUT4 transporters to the cell surface, reducing the need for insulin secretion during exercise.

“When insulin hits the insulin receptor on a muscle, it sends a cascade of chemical reactions inside the muscle that ultimately results in a tube called called the group four transporter, being raised to the surface of the muscle and translocating across the membrane.”

“So they found that this muscle contraction... stimulates pathways to translocate those GLUT4 transporters to the surface. And this is why the pancreas in regular people who don't have type 1 diabetes decreases insulin secretion about 50%. during exercise because the muscle, they do the rest.”

“what you said after that is you explained how non-insulin dependent glucose works, which is Somehow just the contraction of the muscle So something that's going on inside the house squeezes and out comes the same beautiful GLUT4 transporter, which now allows the same passive diffusion of glucose into the cell, but this time it didn't require insulin.”

“now we have a second um way to translocate those Transporters that not many people know about and that's muscle contraction right this is the this is the insulin independent glucose uptake”