Rhonda Patrick· PhD
so energy balance really matters sleep really matters so uh both acute and chronic disruptions of sleep will impair that system it's not entirely clear Why by the way the experimental evidence is undeniable and these are experiments that are so easy to do well that they're unambiguous Right Where You disrupt people's sleep you know you take if you just took a normal group of people and you did like what's called a ug glycemic insulin clamp which is a an experiment um where you you run IV glucose and IV insulin into people and and you basically run a fixed amount of insulin into somebody and then determine how much glucose you need to put in to keep their glucose level fixed that's called a ug glycemic keep glucose fixed um that's a that's the gold standard for measuring insulin sensitivity so you do that test on somebody and then for a week sleep deprive them for you know down to five or six 4 hours a night call it four four would be very dramatic uh within days you'll see like a 50% reduction in their ability to dispose of glucose with no other difference no dietary difference no exercise difference so we don't know exactly why that's happening but it's a very repeatable observation so sleep disruptions impair this um energy imbalance uh impaires this hormonal changes impair this right so as we age uh both the reduction in estrogen and testosterone impair this hypercortisolemia impairs this uh and then of course inactivity is the is the is the greatest thing that drives this