Paul Saladino· MD
so when we are calorically overfed we become insulin resistant because of inflammation
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so when we are calorically overfed we become insulin resistant because of inflammation
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overfeeding can trigger inflammation overfeeding can trigger insulin resistance so this is all kind of a it's all connected right if we over feed on carbs and fat together we can trigger insulin resistance
the two things that I think are driving insulin resistance are inflammation and over feeding of mixed macronutrients
it's very clear from many of the studies that you and I both looked at that that when we over feed people mixed macronutrients they become insulin resistant in the same way because the adipocytes are just totally full yeah you can start in in the Western sort of a western style die over feeding studies you can make somebody instant resistant with them within a couple of days by just over feeding them a western-style diet they don't even have to get super fat no and that's that's probably an inflammatory effect as well