High levels of lipolysis and resulting free fatty acids block glucose uptake and the effects of insulin at the receptor level, preventing glucose metabolism.

“where if you're significantly overweight and orobes you will have high higher than normal lipolysis now lipolysis is known to block the uptake of glucose it's known to block I mean the free fatty acids but they're coming from the liposes it blocks the effects of insulin at the receptant level blocks glucose uptake”

“and if you turn off lipolysis different ways then you rapidly induce glucose consumption”