Insulin resistance negatively affects the glycocalyx and impairs nitric oxide synthesis, damaging the endothelium.

“insulin resistance you said diabetes that's an interesting mechanism to think about how does insulin resistance we know that postprandial hyperglycemia rising of the blood sugar after a meal what people might be able to see with that continuous glucose monitor that affects the glycocalyx negatively that's probably going to impair nitric oxide synthesis all of these things insulin resistance probably being one of the key ones for most people in Western society it's damaging the endothelium”

“if you are getting post prandial hyperglycemia you are damaging your endothelium”