Paul Saladino· MD
this is a study which affects of dietary fructose restriction on liver fat de novo lipogenesis and insulin kinetics in children with obesity again robert lustig is one of the authors and perhaps one of the most well-known popularizers of this concept this is an interesting study it says compared with baseline on day 10 liver fat decreased from a median of 7.2 percent to 3.8 percent great the um de novo lipogenesis the dnl area under the curve decreased from 68 percent to 26 percent anova lipogenesis is the biochemical process in the liver by which fructose is made into fat so that is not a good thing generally it happens at a very very low rate in humans uh and again this is not the dna rate it is just the dnl the denova lipogenesis area under the curve and the insulin kinetics improved these changes occurred irrespective of baseline liver fats the conclusions are short term nine days iso caloric so same calories no calorie restriction here fructose fructose restriction decreased liver fat good thing visceral adipose issue good thing andenova lipogenesis all good things and improved insulin kinetics in children with obesity these findings support efforts to reduce surgery consumption so this is a very striking study and if you look here i perhaps should have given a little bit more detail there were 41 children in study ages 19 18 years old all had meals provided for nine days so they had essentially significantly decreased levels of processed sugar in the diet sugar sweetened beverages etc which was the