Paul Saladino· MD
in the absence of hemochromatosis i think that heme iron is a red herring and I'll tell you why heme iron has only been shown to be a carcinogen in rodent models in which they were fed
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
in the absence of hemochromatosis i think that heme iron is a red herring and I'll tell you why heme iron has only been shown to be a carcinogen in rodent models in which they were fed
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the working group cited compounds such as n nitroso compounds heterocyclic amines and heme iron as uh causing cancer this is the mechanistic basis but when you look at the evidence there there the evidence from in vitro studies utilize conditions that are not necessarily relevant for a normal dietary intake do not provide sufficient evidence a lot of the studies done on animals um tested for the promotion of pre-cancerous conditions utilizing diets low in calcium high in fat contained with exaggerations of heme exposure that in many instances represented intakes that were orders of magnitude above the normal dietary consumption of red meat and then we're talking orders of magnitude that's 10 to 100 x not 2x
animal studies they go on utilize models that tested promotion of pre-neoplastic pre-cancerous conditions utilizing a diet that is low in calcium high in fat mostly seed oils combined with exaggerations of heme exposure that in many instances represented intakes that were orders of magnitude above normal dietary consumption of red meat
animal studies utilize models that tested promotion of pre-cancerous pre-neoplastic conditions utilizing diets low in calcium this is a common trick or a common problem with animal research on heme heme iron or any of these compounds from meat in animal models and cancer they put the animals on a low calcium diet which we know is pro-cancerous and when they give the animals enough calcium they don't get cancer from heme or heme iron