Andrew Huberman· PhD
Now, is that going to cause any health problems? Probably not in the long term, especially, if you're still controlling calories.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Now, is that going to cause any health problems? Probably not in the long term, especially, if you're still controlling calories.
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But just because your body has like upregulated these systems, dealing mostly with fat and glucose production rather than glucose metabolism, so now if you start taking glucose or carbohydrate back in, like for example, you get somebody-- or a glucose tolerance test after they've been on keto, they'll do pretty terribly at it.
Like for example, if you've been on a ketogenic diet and all of a sudden, you move to a higher carb diet, you'll be basically insulin resistant for just a short period of time.
A few weeks.
but what happens is then if you give somebody a boatload of carbohydrate and they've been on on a keto diet for a long period of time those cells have still turned down the insulin signal right so you're gonna get this massive spike in blood sugar and say holy crap this guy's has insulin resistance but if you had to meet some carbohydrates for three or four days you know this is probably somebody who in that interim improve their lean particularly if they were overweight or instant resistant before you know they've improved their body composition potentially maybe lost some weight you know their metabolic health has almost certainly improved but you just need to give them some carbohydrate for them to like turn that turn that signal back on so this is its complex physiology really no whiteboard I love this conversation so what Tommy is saying I'll just try and summarize it or re regurgitate it for people in a different way and hopefully it'll become even more clear during states of low carbohydrate consumption of a diet the body does something that is natural called physiologic insulin resistance at the level of the muscle or glucose sparing is probably a better word and so what's happening there and there are studies which show that even one low-carb meal at night can do this and so pregnant women who are doing a glucose tolerance test or a glue cola the next day should not be doing a low carb meal or they can do a low carb meal if they want to but if you do if a pregnant woman does a low carb meal the night before a glucose tolerance test they can look insulin resistant the next day because that test is sort of flawed right and what's going on there is that when we increase the amount of fat in our diet and when we decrease the amount of carbohydrates there are different signals from the adipose tissue because of declining levels of insulin right? what we know is that if we don't eat carbohydrates if we eat a high if we eat a high fat low carb diet with a moderate amount of protein insulin signal drops