A high-fat diet with significantly reduced carbohydrates and moderate protein is necessary to achieve therapeutically relevant levels of ketones for conditions like neurological disorders.

“If you are not in a state of hyperketonemia, elevated ketones, you're technically not on a ketogenic diet. And what most people don't really appreciate is that to really get higher levels of ketones that are therapeutically linked to what it's used to treat, which is like neurological disorder, seizures, and things like that, you really have to increase the fat...drop the carbohydrates especially but moderate the protein and really consume a really high-fat diet.”