David Sinclair· PhD
Starvation hormone FGF21 increases survival in mice by 30% in males and 40% in females without decreasing food intake & apparently not via the usual suspects, NAD+, AMPK or mTOR.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Starvation hormone FGF21 increases survival in mice by 30% in males and 40% in females without decreasing food intake & apparently not via the usual suspects, NAD+, AMPK or mTOR.
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the other player that seems to be important particularly in um total protein restriction is uh a protein called fgf21 fiber fiberblast growth factor 21 that is uh secreted in response to a low protein diet and then has effects on liver metabolism and and also inhibition of M or reduction of igf-1 so that seems to be required for the lifespan extension that is seen from protein restriction in mice potentially partially Upstream of of mtor and and liver metabolism