David Sinclair· PhD
The original 2008 paper linking DNA 🧬 damage to epigenetic noise 🔈 & aging in mammals @CellPressNews
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
The original 2008 paper linking DNA 🧬 damage to epigenetic noise 🔈 & aging in mammals @CellPressNews
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Here’s ITOA, which explains how DNA damage (and other stresses) can produce epigenetic noise that could lead to aging, in part, via dysregulation of developmental genes (see also Oberdoerffer et al, Cell, 2009 and Yang et al, Cell, 2023)