Andrew Huberman· PhD
Some people have a mutation in the same channel where they make too much of this channel so they feel too much pain.
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Some people have a mutation in the same channel where they make too much of this channel so they feel too much pain.
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So, there are these interesting mutations in a sodium channel, so another channel. But the sodium channel turns out that if the channel is overactive because of a mutation, you'll have excessive pain. So, these patients are highly sensitive. But then, if the channel is essentially unable to function, then these patients have lots of pain, and that's equally bad. Many of these patients actually will die because they can't sense pain at all.