Insufficient carbon dioxide in tissues is problematic for organs like the liver, lungs, and stomach due to shifts in pH regulation.

“Now, of course, that's also just emphasizing the effects of overbreathing and lack of carbon dioxide on the brain. There are hundreds, if not thousands of studies showing that when we don't have enough carbon dioxide in the tissues of our body, that's also problematic for all the tissues-- the liver, the lungs themselves, the stomach, et cetera-- that relate largely to shifts in pH because of the fact that carbon dioxide strongly regulates the acidity, alkalinity of the blood and the tissues that that blood supplies nutrients to, including carbon dioxide.”