The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Our lab and collaborators including Bruce Ksander @MassEyeAndEar and @YuanchengLu have previously demonstrated that it is indeed possible to reverse cellular aging and restore youthful functions to tissues in vivo, without uncontrolled cell growth by virally-introducing a subset Yamanaka genes into cells, Oct4, Sox2 and Klf4. This appears to be remarkably safe in animals
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
The 2020 discovery that expressing only three of the Yamanaka factors – Oct, Sox and Klf (OSK) – could rejuvenate cells without returning them to a pluripotent state turned in vivo reprogramming into a clinical possibility
We found that there are three genes that are normally turned on in embryos that keep them young, that we could turn on again in the adult animal and in human cells.
So we found that a combination of three of these genes and leaving out the other two dangerous ones, was a perfect way to reset the age of the body, without causing cancer.