David Sinclair· PhD
Centenarians don’t just live longer, they get sick later, and their diseases progress more slowly.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Centenarians don’t just live longer, they get sick later, and their diseases progress more slowly.
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if you are genetically blessed to become a centenarian the gift you got is that you have genes that delay your receipt of chronic disease by what appears to be about 20 years
their superpower is not that they survive better when they get diseases it's just that they phase shift when those diseases hit them they just you know when they're 80 they're just acting like physiologically 60 year olds but you know once they get cancer and once they get heart disease and once they get alzheimer's disease they're not bulletproof they just happen to be able to dodge bullets better
their aging is slowed and and when i'm saying they're aging from an age-related disease perspective they live 30 years longer than a cohort that's 20 years younger than them i mean their friends died when they were between 40 and 60. so they already more than doubled life expectancy right their aging has been delayed what happens though their aging has been delayed enough to prevent age major age-related diseases but it's not obviously that they didn't age so when they get to their end of life they are just almost frail enough that whenever disease they get it kills them
they don't seem to have magical protection from a disease once they get it when they get cancer they're just as hosed as the rest of us when they get heart disease they're just they're just as bad off as the rest of us but they get a phase shift they get a 20-year 20 sometimes 30-year phase shift in when they're going to get the disease
when you look at near barzillai's work with centenarians the overwhelming statement here is they get chronic diseases later they don't live longer with them
it's not only that they live long they get variety of age-related disease 20 30 years later
their superpower is simply delaying the onset of bad things like bad things just happen to them 20 to 25 years later