Bcl-2 inhibiting senolytic drugs do not induce apoptosis in normal, healthy eye cells, only in diseased cells.

“interestingly we've shown in animals that they don't cause that to happen in normal healthy eyes they only target cells that have been damaged by the disease process and the stress associated with disease process”

“diseases of the eye is you have a series of these untreatable diseases that make you blind where we think senescence could play a role and we're going to explore each of these in the clinic”

“both of them are inhibitors of the bcl-2 protein family so these are molecules that inhibit inhibitors of apoptosis so they cause cells to enter program to solve death”

“the apoptosis program only turns on in the disease State and it was a pretty awesome result because you can see the selectivity of molecules in a living creatures eye”

“so now they're looking at the eye because again it's it's a nice indication where for some of these eye diseases there isn't any solution and you you can in principle target it quite precisely to the eye so yeah i think that is exactly the strategy that people will be taking”