The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
we use an awful lot of mice because that gives us a lot of statistical power we want to be sure that we will have enough mice present that if a particular drug extends life span by eight or ten percent will pick it up almost all the time eighty percent and ninety percent of the time
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from a statistical standpoint you power to 80 percent for an 8 to 10 detection rate and to put that in english it means you need an awful lot of animals yes each year each of the three sites will have 50 males and 50 females on each drug and also 100 male controls and 100 female controls
we wanted to have at least an 80% chance of picking up a significant result even if one of the three sites had a disaster like an air conditioning failure or a viral infection so far we've only had something like that happen once but um we said let's be ultra conservative we want to have an 80% chance of picking up an effect that's at least a 12 12% effect up or down a two-sided test even if only two sites survive
at each site we are using 100 male controls and 100 female controls so pooling that's 300 males and 300 females in the control group each year and for each drug we use 50 males and 50 females that is half as many as the controls again at each site so for any one drug 50 * 3 is 150 we have 150 male mice distributed across three sites and 150 female mice distributed across three sites
in practice that we have 80% power to detect drugs will give us like an 8% increase or a 10% increase 12% was kind of conservative
in other words if you're doing a five drug trial there will be a total of 300 male 300 female control but there will be 750 total male 750 total female on the combination of drugs 150 for each
we wanted to have at least an 80% chance of picking up a significant result even if one of the three sites had a disaster like an air conditioning failure or a viral infection so far we've only had something like that happen once but um we said let's be ultraconservative we want to have an 80% chance of picking up an effect that's at least a 12 % effect up or down a two-sided test even if only two sites survive