Herpes simplex 1 virus resides on the fifth cranial nerve and can cause tingling and pain in its dermatome when it flares up.

“So for those of you listening, I've just kind of put my right hand across my face and to sort of simulate the three branches, the trigeminal aspect of this nerve. So tri three. Now, when the herpes virus flares up, as they say, in response to stress or other factors, the virus inflames that nerve and people experience tingling and pain on the nerve. Sometimes they'll get a cold sore or a blister on their lip or near their mouth, sometimes they'll get a collection of those. And that's because that dermatome is actually inflamed.”