The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
increasingly we have a better sense of what the non-coding regions do um we have better ability to interpret and recognize genetic Varian and so I would say as the sequencing costs have been coming down there's more of a shift to going to genomes rather than exomes
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
but truly most of what is medically used at this point um is in the coding space so even if you're sequencing a genome it's still focused on the coding regions
it certainly was the case that a few years ago not that long ago it was so expensive to sequence a genome that we rarely did it it was really just cost prohibitive the exome was a really good shortcut because we didn't know what a lot of the other information meant anyway
increasingly we have a better sense of what the non-coding regions do uh we have better ability to interpret and recognize genetic Varian and so I would say as the sequencing costs have been coming down there's more of a shift to going to genomes rather than exomes