Broader aging clocks incorporating multiple biomarkers may be more optimistic than methylation-specific epigenetic marks for predicting healthspan.

“i think you run the risk with the epigenetic clocks that you're only informing on a subset of the biological aging processes and if you look more broadly you're much more likely to get a holistic picture at the whole individual level”

“my personal um intuition is that the clocks so i would call that more of a general aging clock a putative agent clock i guess i should say that the the the putative aging clocks that incorporate things beyond epigenetics are much more likely to actually work in a useful way in humans”