Efficacy assessment metrics for the IHHT protocol include hypoxia efficacy (SpO2%, pyruvate/lactate), sleep and recovery (RHR, HRV), fitness/performance (VO2 Max, strength), cardiovascular health (BP, VEGF), lung capacity (spirometry), metabolic markers (glucose, lipids), inflammation (hs-CRP, interleukins), brain health (pTAU217, brain age), and hematological markers (EPO, RBCs).

“Efficacy Assessment Metrics: + Hypoxia Efficacy: Real-time device tracking (SpO2%), blood pyruvate/lactate. + Sleep and Recovery: Sleep tracking, resting heart rate (RHR), heart rate variability (HRV) with sympathetic/parasympathetic index (SDNN, RMSSD, HF/LF). + Fitness, Performance, and Recovery: VO2 Max, exercise capacity (maximal wattage, repetitions to exhaustion), muscle strength, heart rate recovery. + Cardiovascular and Arterial Health: Central pulse markers, blood pressure, VEGF, MMP9/2, F2-isoprostane. + Lung Capacity: Spirometry. + Metabolic Markers: Blood sugar control, lipid profiles, body composition. + Systemic Inflammation: hs-CRP, interleukins (IL-6, IL-10), TNF-alpha. + Brain health: pTAU217, S-100B, Kernel brain age, MRI brain structure and age. + Hematological markers: Erythropoietin (EPO), hematocrit, red blood cell count (RBCs), hemoglobin”